姓    名：吴稚伟                                      

专业方向：免疫病理和药理

办公电话：15996240450

电子邮件：wzhw@nju.edu.cn

通讯地址：云南省大理州大理市下关镇万花路22号大理大学下关校区

简历：1982年本科毕业于南京大学；1991年获英国爱丁堡大学博士学位；1990-1997年在美国私立纽约大学接受博士后训练，1997-2006分别在洛克菲勒大学和宾夕法尼亚大学Leon Levy研究中心担任助理教授和高级研究员职位。2006引进南京大学，任南京大学教授（二级），博导，创建公共健康医学中心并任主任，南京大学生命分析化学国家重点实验室副主任。曾担任艾滋病疫苗基础研究专项（973项目）课题负责人，国家十一五，十二五和十三五传染病重大专项负责人。2025年起，全职受聘大理大学教授、博导。兼任WHO性传染病、生殖健康领域专家顾问，私立纽约大学客座教授和英国南汉普顿大学社会科学和生物统计学院Associate Member，教育部“病毒学知识领域专家协作组首席专家”。

研究领域：长期从事感染免疫、病毒性感染病理、疫苗和抗病毒药物的研究和开发。主要的学术活动集中在如下几方面：（1）病毒感染致病的免疫病理机制以及病毒逃逸宿主免疫的分子机理（2）病毒诱导的免疫稳态失衡、炎症和慢性疾病的关系（如炎症性肠炎、神经渐行性退化症、糖尿病）（3）细胞外囊泡在病毒感染、传播和免疫调控中的作用（4） 纳米单克隆抗体抗病毒药物和技术。

代表论著（限10篇）：

1. Wu, X.*^#, Zhu, L.^#, Liang, S., Chang, Z., Wang, Y., Zou, Q., Xu, Z., Zhang, D., Hu, J., Geng, S., Li, Z., Yu, W., Hu, Z., Chen, M., Cao, K., Jia, B., Wei, H., Cai, R., Long, J., Yang, X., Yang, Q., Yu, Z., Shi, L., Xu, B., Zheng, Y., Meng, S., Cai, J., Zhou, G., Zhu, K., Dou, Y., Lou, Z. ^(*), Li, M. ^(*), Wu, Y. ^(*), & Wu, Z*. A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models. Science Translational Medicine, Cover Article, 19 Nov 2025. Vol 17, Issue 825. DOI: 10.1126/scitranslmed.ady9025
2. Qiao You, Jing Wu, Chaoyong Wang, Deyan Chen, Shiji Deng, Yurong Cai, Nan Zhou, RuiningLyu, Yajie Qian, Yi Xie*, Miao He*, Zhiwei Wu*. Astrocytes-derived LCN2 Triggers Viral Muscle Soreness via Accumulating Lactate. Science Advances. 11, eadt9837 (2025) 16 May 2025. https://www.science.org.
3. Bingxin Liu, Xiaoyan Tian, Linrun Li, Na Jiang, Min Cheng, Zhiwei Wu*. SFTSV Induced Liver Ferroptosis Through m6A-related Ferritinophagy. Autophagy（14 May 2025）. DOI: 10.1080/15548627.2025.2503564.
4. Yajie Qian, Jing Wu, Weidong Yang, Ruining Lyu, Qiao You, Jingjing Li,
   Qin He, Yuan Zhuang, Wenmei Wang*, Yong Wang*, Yanan Zhu*, Zhiwei Wu*,Deyan Chen*. FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway. Nature Communications (2025) 16:1519. https://doi.org/10.1038/s41467-025-56615-1
5. Deyan Chen，Jing Wu, Fang Zhang, Ruining Lyu,Qiao You, Yajie Qian, Yurong Cai, Xiaoyan Tian, Hongji Tao, Yating He, Waqas Nawaz, Zhiwei Wu*. Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice. EMBO Molecular Medicine (2024). https://doi.org/10.1038/s44321-024-00128-9.
6. Linjing Zhu,Bilian Huang, Xiangyao Wang, Fengfeng Ni, Mingjun Ao, Ruoke Wang, Bin Zheng, Chen Chen, Jing Xue, Lin Zhu, Chenbo Yang, Lingen Shi, Shengya Geng, Jiaqian Hu, Mengshi Yang, Doudou Zhang, Ping Yang, Miaomiao Li, Yuncheng Li, Qinxue Hu, Sheng Ye, Peng Zheng, Hongxia Wei, Zhiwei Wu^*, Linqi Zhang^*, Yaxin Wang^*, Yalan Liu^*, Xilin Wu*. Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration. Nature Communications (2024) 15:6961. https://doi.org/10.1038/s41467-024-51414-6.
7. Mengmeng Ji, Jiaqian Hu, Doudou Zhang, Bilian Huang, Shijie Xu, Na Jiang, Yuxin Chen*, Yujiong Wang*, Xilin Wu*, and Zhiwei Wu*. Inhibition of SFTSV replication in humanized mice by a subcutaneously administrated anti-PD1 nanobody. EMBO Molecular Medicine(2024). https://doi.org/10.1038/s44321-024-00026-0
8. Rui Zhang, Yuxuan Fu, Min Cheng, Wenyuan Ma, Nan Zheng, Yongxiang Wang*, Zhiwei Wu*. sEVs^RVGselectively delivers antiviral siRNA to fetus brain, inhibits ZIKV infection and mitigates ZIKV-induced microcephaly in mouse model. Molecular Therapy (2021), https://doi.org/10.1016/j.ymthe.2021.10.009.
9. Frederik J. Verweij, Leonora Balaj, Chantal Boulanger, David RF Carter, Ewaldus B Compeer, Gisela D’Angelo G, Samir El Andaloussi, Jacky G. Goetz, Julia Groß, Vincent Hyenne, Eva-Maria Krämer-Albers A, Charles Lai, Xavier Loyer, Alex Marki, Stefan Momma, Esther Nolte ‘t Hoen, Michiel D Pegtel, Hector Peinado, Graça Raposo, Kirsi Rilla, Hidetoshi Tahara, Clotilde Théry, Martin Van Royen, Roosmarijn Vandenbroecke, Ann Wehman, Kenneth Witwer, Zhiwei Wu, Richard Wubbolts, Guillaume van Niel. The power of imaging to understand EV biology in vivo. Nature Methods(2021). https://doi.org/10.1038/s41592-021-01206-3.
10. Peixin Song, Nan Zheng, Yong Liu, Chen Tian, Xilin Wu, Xiaohua Ma, Deyan Chen, Xue Zou, Guiyang Wang, Huanru Wang, Yongyang Zhang, Sufang Lu, Chao Wu, Zhiwei Wu*. Deficienthumoral response and disrupted B cell immunity are associated with fatal SFTSV infection. Nature Communications (2018) 9:3328/DOI: 10.1038/s41467-018-05746-9. 

承担科研项目情况（限5项）：

1. 重大基础研究专项（973）：人类免疫缺陷病毒生物学和免疫应答机制研究 (2006CB504203). 2006-2010, 金额：200万元。课题三负责人。
2. 十一五传染病重大专项：杀微生物剂在预防艾滋病性传播的应用基础研究 (2008ZX10001-015).2008-2010， 2870万元。首席负责人。
3. 十二五传染病重大专项：新型杀微生物剂的临床前和临床研究 (2012ZX10001007-009).2011-2015， 1057万元。首席负责人。
4. 十二五传染病重大专项：优化诱导广谱中和抗体的HIV基序疫苗(2013ZX10001005-003). 2013-2015， 245万元。课题负责人。
5. 十三五传染病重大专项：基序表位设计用于突发传染病快速诊断POCT和治疗抗体的研发(2018ZX10301406). 2018-2020，1517万元。首席负责人。