李丽娟

姓名：李丽娟

专业方向：药理学

办公电话：0872-2219120

电子邮件：lelejuan@126.com

通讯地址：云南省大理州大理市下关镇万花路22号大理大学下关校区

简历：

教授，博士生导师，大理大学科技处处长。主要从事神经炎症与代谢性疾病的中枢调控机制研究以及昆虫药药效物质基础及作用机制研究。发表学术论文76篇（其中SCI论文31篇），出版专著1部。以通讯作者（含共同通讯）在 Journal of ethnopharmacology vol、International Immunopharmacology、Frontiers in Public Health、Alpha Psychiatry 等期刊发表了相关研究成果，主持云南省科技厅项目3项，大理州科技厅项目1项，大理大学，科研发展基金重点项目1项；参与国家自然科学基金项目1项。曾获云南省卫生科技成果三等奖、大理州科技进步三等奖。培养硕士研究生15人。

研究领域：神经炎症与代谢性疾病的中枢调控机制研究；昆虫药药效物质基础及作用机制研究

代表论著：

Hairong Zhao,Xue Wang,Kunkun Li, Jie Zhao, Jiapeng Wang,Yihao Che, Jingyu Zhang, Huai Xiao, Dexiao Wang, Qian Wang, Lijuan Li*, Yu Zhao*, Chenggui Zhang*. TLR4-antagonizing bioactive components from Blaps rynchopetera polysaccharide-glycoprotein complex: Biolayer interferometry-mass spectrometry identification and NF-κB-mediated anti-inflammation. Journal of ethnopharmacology vol. 2026;362:121328.
Jiang, Le; Ma, Rui-Xue; He, Er-Shu; Zheng, Xiao-Ye; Peng, Xin; Ma, Wen-Hao; Li, Ying; Li, Han-Wei; Zhang, Xue-Yan; Ji, Jie-Yu; Li, Yan-Jiao; Qu, Shang-Lan; Li, Li-Juan*; Gong, Zhi-Ting*; DNA methylation regulates the extinction of fear memory, World Journal of Psychiatry, 2025, 15(7): 1-11.
Yanqiu Yu,Xin Su, Ying Yang, Haifeng Xue, Bo Liu, Yuqi Sun, Ruxin Wang, Xinxin Mo, Hongye Luo, Lijuan Li, Xianzhang Tian, Yanjie Yang, Zhengxue Qiao, Liping Li, Tong Xie,Siman Li, Lijing Liu, Yucheng Zhang, Joseph T F Lau*. Emotional Dysregulation-Mediated Associations Between Guilt Proneness, Shame Proneness, and Internet Gaming Disorder Among Chinese University Students: Cross-Sectional Survey. J Med Internet Res. 2025;27:e74052.
Xiao-Jing Lei,Hong-Mei Sun, Yun-Xia Qu, Qing-Zhu Xu, Ying Zhou, Huai Xiao, Li-Juan Li*, Zhi-Bin Yang*. Research overview of ethnic medicines for the treatment of rheumatoid arthritis. Front Pharmacol. 2025;16:1662130.
Rui She, Lijuan Li, Qian Yang, Jianyan Lin, Xiaoli Ye, Suliu Wu, Zhenggui Yang, Suzhen Guan, Jianxin Zhang, Joseph Laul*. Resilience and Mindfulness as Factors of Posttraumatic Stress and Growth Among Chinese Healthcare Workers During the COVID-19 Pandemic: Mediation via Adaptive Coping and Stigmatisation. Stress Health. 2025;41(3):e70037.
Lijuan Li,Kunkun Li,Yu Mi,Xiumei Wu,Youhong Zhong,Chenggui Zhang,Peng Wang*, Hairong Zhao*. Isolation, characterization, and genomic analysis of a novel phage WSPA with lytic activity against Serratia marcescens. Microbiol Spectr. 2025;13(9):e0271624.
Ershu He; Ruixue Ma; Shanglan Qu; Xiaoye Zheng; Xin Peng; Jieyu Ji; Wenhao Ma; Xueyan Zhang; Ying Li; Hanwei Li; YanjiaoLi; Lijuan Li*; Zhiting Gong*; L-methionine and the L-type Ca2+ channel agonist BAY K 8644 collaboratively contribute to the reduction of depressive-like behavior in mice, Frontiers in Neural Circuits, 2024, 18
Wang, Dexiao; Zhao, Jie; Zhang, Jingyu; Lv, Changling; Bao, Shuangyan; Gao, Pengfei; He, Miao;Li, Lijuan*; Zhao, Hairong*; Zhang, Chenggui*; Targeting TNF-α: α : The therapeutic potential of certolizumab pegol in the early period of cerebral ischemia reperfusion injury in mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 137
Wang, Nan; Yin, Chunlei; Feng, Ruiqi; Jia, Rong; Zhou, Liguo; Wu, Wenyu; Yu, Haiyan; Ye, Yuan; Gong, Zhiting*; Li, Lijuan*; Analysis of Intestinal Microbiota in Schizophrenic Patients with Type 2 Diabetes Mellitus, Alpha Psychiatry, 2024, 25(3): 375-381
Qian Zhang; Miao Guo; Tianyi Chen; Huizhi Cheng; Qianwen Yang; Zhuohui Zhao; Rong She; Xiaoyan Yang; Wen Xiao; Xu Yang*; Lijuan Li*; Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term, Frontiers in Public Health, 2022;10:1024864

承担科研项目情况：

云南省科技厅，院士(专家)工作站项目，项目编号：202605AF350069，名称：云南省刘刚专家工作站，01至2028.12，180万元，在研，主持。
云南省科技厅，地方高校联合专项（重点项目），项目编号：202501BA070001-004，名称：靶向CCR5垂钓大胡蜂毒液中治疗卒中后认知功能障碍的活性肽及结构基础研究，09至2028.08，40万元，在研，主持。
大理州科技局，基础研究专项，项目编号：20232901A020007，名称：DNA甲基转移酶3A在精神分裂症“微生物-肠-脑轴”调控中的作用机制研究，2023-03至2026-02，40万元，资助期满，主持。
大理大学，科研发展基金重点项目，项目编号：FA2023ZD020，名称：肠道微生物组在精神分裂症中的作用机制研究，01至2025.12，15万元，资助期满，主持。
国家自然科学基金（地区基金），项目编号：82360231，名称：小鼠背侧海马中的黑素皮质素受体- 1(MC1R)在改善学习记忆中的作用及机制研究，01至 2027.12，32万元，在研，参与。