姓   名：赖泳

专业方向：药理学    

电子邮件：laiyong8879@163.com

通讯地址：云南省大理州大理市下关镇万花路22号大理大学下关校区，药学实验楼420，临床药学教研室

简   历：

赖泳，硕士，教授，硕士生导师，云南省“兴滇英才”教学名师，校级中青年学术带头人。云南省药理学会药物基因组学副主任委员，云南省医学会临床药学分会委员。现任《大理大学学报》杂志编委。药理学省级一流课程和“云南省药理学研究生导师团队”负责人。

主持国家自然科学基金 2 项，主持或参与云南省教育厅重大专项等药理学相关课题 10 余项，以第一或通讯发表论文 60 余篇 (SCI 16 篇) ；主编、副主编教材各 1 部；

研究领域：中药药理、临床药理

代表论著：

1. Ai, X., Huang, H., Miao, Z., Zhou, T., Wu, H., Lai, Y. 2021. Relationship between xanthine oxidase gene polymorphisms and anti-tuberculosis drug-induced liver injury in a Chinese population. Infect Genet Evol, 93, 104991.
2. Chen, H. D., Jiang, M. Z., Zhao, Y. Y., Li, X., Lan, H., Yang, W. Q., Lai, Y. 2023. Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-κB signaling pathway in rats. J Ethnopharmacol, 300, 115691.
3. Ding, W., Cao, C., Gao, Y., Zhou, X., Lai, Y. 2020. Inhibition of CYP3A4 and CYP3A5 expression by scutellarin is not mediated via the regulation of hsa-miR-27a, 27b, 148a, 298 and 451a levels. Xenobiotica, 50(11), 1267-1274.
4. Hu, C., Li, Y., Liu, Y., Lai, Y., Ding, L. 2022. A Sensitive HPLC-MS/MS Method for Determination of Obeticholic Acid in Human Plasma: Application to a Pharmacokinetic Study in Healthy Volunteers. J Chromatogr Sci, 60(6), 545-550.
5. Huang, H., Cao, C., Miao, Z., Yang, X., Lai, Y. 2023. Scutellarin Mediates Cytochrome P450 3A4 and 2C19 Expression via Pregnane X Receptor and Constitutive Androstane Receptor. Curr Mol Pharmacol, 16(6), 640-653.
6. Huang, H. X., Wu, H., Zhao, Y., Zhou, T., Ai, X., Dong, Y., Lai, Y. 2021. Effect of CYP2C9 genetic polymorphism and breviscapine on losartan pharmacokinetics in healthy subjects. Xenobiotica, 51(5), 616-623.
7. Miao, Z., Lai, Y., Zhao, Y., Chen, L., Zhou, J., Li, C., Lan, H. 2020. Scutellarein Aggravated Carbon Tetrachloride-Induced Chronic Liver Injury in Gut Microbiota-Dysbiosis Mice. Evid Based Complement Alternat Med, 2020, 8811021.
8. Miao, Z., Lai, Y., Zhao, Y., Chen, L., Zhou, J., Li, C., Wang, Y. 2021. Protective Property of Scutellarin Against Liver Injury Induced by Carbon Tetrachloride in Mice. Front Pharmacol, 12, 710692.
9. Wu, R., Wang, X., Cui, P., Chen, W., Yang, W., Lai, Y. 2024. Efficacy and safety of generic cefoperazone/sulbactam versus branded cefoperazone/sulbactam in the treatment of bacterial infections: a systematic review and meta-analysis. J Chemother, 1-11.
10. Zhao, Y., Miao, Z., Jiang, M., Zhou, X., Lai, Y. 2021. Effects of breviscapine and C3435T MDR1 gene polymorphism on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers. Xenobiotica, 51(3), 366-372.

承担科研项目情况：

1.国家自然科学基金 (地区基金) , 项目编号：81360511, 名称：灯盏花素对细胞色素 P450 酶和蛋白转运体活性的影响及机制探讨, 2014/01‒2017/ 12, 50 万元, 在研, 主持。

2.国家自然科学基金 (专项基金) , 项目编号：81241139, 名称：灯盏花素对CYP450代谢酶和蛋白转运体及其调控因子影响的研究, 2013/01‒2013/ 12, 10 万元, 已结题, 主持。

3.云南省教育厅重大专项项目, 项目编号：ZD2014013, 名称：“肝龙胶囊”含药血清抗肝纤维化机制研究, 2014/10-2016/ 10, 10 万元, 已结题, 主持。

4.云南省科技厅面上项目, 项目编号：2010ZC141, 名称：相关基因多态性与阿托伐他汀在云南白族冠心病病人中疗效和不良反应相关性研究, 2010/01-2013/ 12, 5.0 万元, 已结题, 主持。