姓    名：杨婉琦

专业方向：药理学

电子邮件：yangwanqi@dali.edu.cn

通讯地址：大理州大理市下关镇万花路22号大理大学下关校区，药学实验楼药理教研室

简    历：药理学博士，副教授，硕士研究生导师。主要承担医药学专业学生《药理学》、《药学综合知识与技能》及《药物毒理学》等课程的教学工作，在大理大学第二十三届及第二十五届教学竞赛中荣获二等奖。研究方向为心脑血管药理及内分泌代谢药理，发表多篇科技论文于Cell Chemical Biology、Journal of Ethnopharmacology、Faseb Journal等国际著名学术期刊，主持云南省科技厅基础研究项目—大黄对多囊卵巢综合征大鼠的作用及机制研究，以及校级科研项目—滇西药用植物与民族医药作用与机制研究。培养硕士研究生9人。

研究领域：动植物民族药对内分泌代谢疾病的作用与靶点研究，以及缺血性纤维化与心肌损伤分子机制研究。

代表论著

[1] Li Yang^#, Qiu Jishuang^#, Zhou Yanru, Jiang Yuanyuan, Li Xin, Weng Ying, Chen Yang, Lai Yong*, Yang Wanqi*. Rhein Attenuates Oxidative Stress-Induced Injury in Human Ovarian Granulosa Cells by Inhibiting the NF-κB—TNF-α/IL-6/PTGS2 Inflammatory Axis. Naunyn Schmiedebergs Arch Pharmacol. 2025, DOI: 10.1007/s00210-025-04906-1

[2] Jiang Yuanyuan^#, Li Jiao^#, Qiu Jishuang, Zhou Yanru, Lai Yong*, Yang Wanqi*. Rsu1 Mediates Caco-2 Colorectal Cancer Cells Proliferation and Migration Via Pi3k/Akt Signaling Pathway. Cell Biochem Biophys. 2025. 83(4): p. 4885-4895.

[3] Yang, Wanqi*^#; Qiu, Jishuang^#; Zi, Jiangli; Li, Yang; Li, Jiao; Guo, Meixian; Zhou, Yanru; Yang, Xiaotong; Lai, Yong*; Effect of Rhei Radix Et Rhizome on treatment of polycystic ovary syndrome by regulating PI3K/AKT pathway and targeting EGFR/ALB in rats. Journal of Ethnopharmacology, 2025. 338(Pt 1): p. 119020.

[4] Rui Wu^#; Xuechang Wang; Pumei Cui; Wei Chen; Wanqi Yang*; Yong Lai*; Efficacy and safety of generic cefoperazone/sulbactam versus branded cefoperazone/sulbactam in the treatment of bacterial infections: a systematic review and meta-analysis. Journal of Chemotherapy, 2024. 36(8): p. 698-708.

[5] Yang, Wanqi^#; Zhuang, Yuting^#; Wu, Hao^#; Su, Shuang; Li, Yuyang; Wang, Chaoqun; Tian, Zhongrui; Peng, Lili; Zhang, Xiaowen; Liu, Junwu; Pei, Xinyu; Yuan, Wei; Hu, Xiaoxi; Meng, Bo; Li, Danyang; Zhang, Yang; Shan, Hongli*; Pan, Zhenwei*; Lu, Yanjie*, Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. Cell Chemical Biology. 2023. 30(10): p. 1248-1260 e4.

[6] Hai-Dong Chen^#; Ming-Zhao Jiang; Ying-Ying Zhao; Xin Li; Hai Lan; Wan-Qi Yang*; Yong Lai*; Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-κB signaling pathway in rats. Journal of Ethnopharmacology, 2023. 300: p. 115691.

[7] Hongwen Xiao; Mingyu Zhang; Hao Wu; Jiaxu Wu; Xiaoxi Hu; Xinyu Pei; Danyang Li; Lu Zhao; Qi Hua; Bo Meng; Xiaowen Zhang; Lili Peng; Xiaoling Cheng; Zhuoyun Li; Wanqi Yang; Qi Zhang; Yang Zhang; Yanjie Lu*; Zhenwei Pan*; CIRKIL Exacerbates Cardiac Ischemia/Reperfusion Injury by Interacting With Ku70. Circulation Research, 2022. 130(5): p. e3-e17  

[8] Tingting Li^#; Yuting Zhuang^#; Wanqi Yang^#; Yilin Xie; Wendi Shang; Shuang Su; Xue Dong; Jiaxu Wu; Wenmei Jiang; Yang Zhou; Ying Li; Xin Zhou; Mingyu Zhang; Yanjie Lu*; Zhenwei Pan*; Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts. FASEB J, 2021. 35(2): p. e21162.

承担科研项目情况：

(1) 云南省科技厅基础研究专项青年项目，202301AU070178，大黄对多囊卵巢综合征大鼠的作用及机制研究，2023/06-2026/05, 5万元, 在研, 主持；

(2) 国家自然科学基金委员会, 面上项目, 52272287, 铜硫族化合物基S-型异质结材料制备及其光动力肿瘤治疗, 2023/01-2026/12, 54万元, 在研, 参与；

(3) 云南省科技厅基础研究重点项目，基于“靶点敲减-靶向垂钓-荧光探针”策略的美洲大蠊调控TGF-β/Smad信号通路抗肺纤维化机制研究，2025/03-2028/2, 50万元, 在研, 参与。