王开玲

   名:王开玲                                       

专业方向:微生物药学

办公电话:0872-2219670

电子邮件:kailingw@dali.edu.cn

通讯地址:云南省大理州大理市下关镇万花路22号大理大学下关校区

简历:副教授。硕士研究生导师。云南省高层次引进人才“千人计划”入选者。主要从事微生物药学、分子生物学教学以及特境微生物药用资源开发与利用研究工作,已在滇西特境特色微生物抗病原活性药用资源发掘领域形成特色研究方向,特别是在抗耐药菌生物膜活性先导化合物发现及其作用机制探讨方面成果显著。先后以副主编身份参编学术专著1部;近五年以一作(含共一)及通讯作者(含共通)共发表学术论文16篇,其中SCI收录论文11篇,北大中文核心期刊论文5篇。篇(其中SCI论文128篇);获授权发明专利2项;主持国家自然科学基金项目3项。培养硕士研究生11人,其中考取博士2人。

研究领域:特境微生物药用资源开发与利用

代表论著(限10篇):

  1. Guo-Jun Zhou , Wei-Jia Xiong, Wei Xu, Zheng-Rong Dou, Bo-Chao Liu, Xue-Li Li , Hao Du , Hai-Feng Li ,Yong-Zeng Zhang, Bei Jiang, Kai-Ling Wang*. Diversity and anti-Infectious components of cultivable rhizosphere fungi derived from three species of Astragalus plants in northwestern Yunnan, China. Journal of Fungi, 2024, 10, 736.
  2. Jia-Jie Ding, Guo-Jun Zhou, Xiao-Jie Chen, Wei Xu, Xing-Mei Gao, Yong-Zeng Zhang, Bei Jiang,Hai-Feng Li *, Kai-Ling Wang. Analysis of microbial diversity and community structure of rhizosphere soil of three Astragalus species grown in special high-cold environment of northwestern Yunnan, China. Microorganisms, 2024, 12: 539. 
  3. Dou Zheng-Rong#, Zhang Fa#, Zhou Guo-Jun, Gong Gao-Fen, Jia-Jie Ding, Fan Xu-Han, Jiang Bei, Wang Kai-Ling*. Varicosporellopsis shangrilaensis nov. (Nectriaceae, Hypocreales), a new terricolous species isolated from the rhizosphere soil of Astragalus polycladusin northwestern Yunnan, China. Phytotaxa, 2023, 600 (4): 230-238. 
  4. Wang Kai-Ling, Dou Zheng-Rong, Gong Gao-Fen, Li Hai-Feng, Jiang Bei. Anti-larval and anti-algal natural products from marinemicroorganisms as sources of anti-biofilm agents. Marine Drugs, 2022, 20: 90/1-90/25. 
  5. Song Zhi-Man, Zhang Jun-Liang,Zhou Kun, Yue Lu-Ming, Zhang Yu, Wang Chang-Yun, Wang Kai-Ling *, Xu Ying*. Anthraquinones as potential anti-biofilm agents against methicillin-resistant Staphylococcus aureus. Frontiers in Microbiology, 2021, 12: e
  6. SongZhi-Man#, Wang Kai-Ling#, Yin Qi, Chen Cheng-Chun, Xu Ying*. Algoriphagus kandeliae nov., isolated from mangrove rhizosphere soil. International Journal of Systematic and Evolutionary Microbiology, 2020, 70(3): 1672-1677.
  7. Zhang Lv#,Wang Kai-Ling#, Yin Qi, Liang Jin-You, Xu Ying*. Ruegeria kandeliae nov. isolated from the rhizosphere soil of a mangrove plant Kandelia candel. International Journal of Systematic and Evolutionary Microbiology, 2018, 68(8): 2653-2658.
  8. Wang Kai-Ling,Song Zhi-Man, Rong Cu-Huang, Hao Ling-Yun, Lai Qi- Liang , Li Shuang-Fei, Xu Ying *Kandeliimicrobium roseum nov., sp. nov., a new member of the family Rhodobacteraceae isolated from mangrove rhizosphere soil. International Journal of Systematic and Evolutionary Microbiology, 2018, 68(7): 2158-2164.
  9. Hui-Na Lin#, Kai-Ling Wang#, Ze-Hong Wu, Ren-Mao Tian, Guo-Zhu Liu, Ying Xu*. Biological and chemical diversity of bacteria associated with a marine flatworm. Marine Drugs, 2017, 15 (9): 281. 
  10. Wang Kai-Ling, Zhang Gen, Sun Jin, Xu Ying, Han Zhuang, Liu Ling-Li, Shao Chang-Lun, Liu Qing-Ai Liu, Wang Chang-Yun, Qian Pei-Yuan*. Cochliomycin A inhibits the larval settlement of Amphibalanus amphitriteby activating the NO/cGMP pathway. Biofouling, 2016, 32(1): 35-44.

承担科研项目情况(限5项)

  1. 国家自然科学基金地区基金项目: 基于抗细菌生物膜活性药源开发的滇西北高寒特境黄芪属植物根际微生物研究,32060032,01-2024.12,在研,主持;
  2. 国家自然科学地区基金项目,82360708, 滇西北高寒特境黄芪属植物根际微生物抗MRSA生物膜活性先导化合物的发掘及其作用机制研究, 2024-01-01 至 2027-12,00万元,结题, 主持;
  3. 国家自然科学基金青年基金项目: 抗污损双吲哚生物碱类化合物的作用机制及其环境生态风险评估,41706155,01-2020.12,结题,主持;
  4. 云南省科学技术厅面上项目,202001AT070022,基于抗生物膜活性药源开发的滇西北特境黄芪属植物根际微生物的研究,2020-09 至 2023-08,00万元,结题, 主持。
  5. 云南省科学技术厅面上项目,202301AT070157,多级联合筛选与表观遗传修饰策略下滇西北高寒特境黄芪属植物根际真菌的抗QS活性药源潜力研究,2023-09 至 2026-08,00万元,在研, 主持。