杨艺玲

   名:杨艺玲                                   

专业方向:药物生物学

办公电话:0872-2257259

电子邮件:1640186607@qq.com

通讯地址:云南省大理州大理市下关镇万花路22号大理大学下关校区药学楼

简历:博士,助理研究员。目前主持大理大学博士科研启动基金项目1项、云南省地方高校联合专项-青年项目1项。迄今在Organic Letters、Journal of Natural Products、Angewandte Chemie International Edition、Phytochemisty等杂志上发表论文10余篇。指导学生参与各类比赛,其中“学创杯”获省级三等奖,并获优秀指导教师。

研究领域:药用植物和微生物的次级代谢产物及其生物合成研究。

代表论著(限10篇):(以标准参考文献格式规范罗列,以时间顺序由近至远,倒序排列)

  1. Chen, W.; Dong, L.-T.; He, P.-M.; Zu, W.-J.; Yang, Y.-L.; Liu, R.; Jiang, B.; Xiao, C.-J., Ten eudesmane sesquiterpenoids from Dobinea delavayiand their antimalarial and lipid-lowering activities. Phytochemistry, 2025, 237, 114535.
  2. Du, W.-H.; Leng, L.; Chen, W.; He, L.-F.; Li, G.; Qiu, Z.; Fang, S.-J.; Yang, Y.-L.; Xiao, C.-J.; Jiang, B., Protoberberine alkaloids from Berberis pruinosaand their antimalarial activities. Fitoterapia, 2025, 185, 106681.
  3. Peter, M.; Zhang, Z.-X.; Yang, Y.-L.; Li, S.-M., Biosynthesis of the Sesquiterpenoid Malfilanol D in Aspergillus ustusImplies Alkyl and Hydride Migrations during the Bicyclo[5.4.0]undecane Skeleton Formation. Organic Letters, 2024, 26 (31), 6670-6674.
  4. Liu, J.; Yang, Y.-L.; Xie, X.-L.; Li, S.-M., A Streptomyces Cytochrome P450 Enzyme Catalyzes Regiospecific C2-Guaninylation for the Synthesis of Diverse Guanitrypmycin Analogs. Journal of Natural Products, 2023, 86 (1), 94-102.
  5. Liu, J.; Harken, L.;Yang, Y.-L.; Xie, X.-L.; Li, S.-M., Widely Distributed Bifunctional Bacterial Cytochrome P450 Enzymes Catalyze both Intramolecular C−C Bond Formation in cyclo-l-Tyr-l-Tyr and Its Coupling with Nucleobases. Angewandte Chemie International Edition, 2022, 61 (21), e202200377.
  6. Peter, M.; Yang, Y.-L.; Li, S.-M., A terpene cyclase from Aspergillus ustus is involved in the biosynthesis of geosmin precursor germacradienol. RSC Advances, 2022, 12 (43), 28171-28177.
  7. Liu, J.; Yang, Y.-L.; Harken, L.; Li, S.-M., Elucidation of the Streptoazine Biosynthetic Pathway in Streptomyces aurantiacus Reveals the Presence of a Promiscuous Prenyltransferase/Cyclase. Journal of Natural Products, 2021, 84 (12), 3100-3109.
  8. Zheng, L.-J.; Yang, Y.-L.; Wang, H.-W.; Fan, A.; Zhang, L.-P.; Li, S.-M., Ustethylin Biosynthesis Implies Phenethyl Derivative Formation in Aspergillus ustus. Organic Letters, 2020, 22 (20), 7837-7841.
  9. Li, W.; Yang, Y.-L.; Yang, L.; Wang, H.; Dong, W.-H.; Cai, C.-H.; Yuan, J.-Z.; Jiang, B.; Mei, W.-L.; Dai, H.-F., New sesquiterpenoids bearing 11-methyl ester group of agarwood. Fitoterapia, 2020, 143, 104557.
  10. Yang, Y.-L.; Li, W.; Wang, H.; Yang, L.; Yuan, J.-Z.; Cai, C.-H.; Chen, H.-Q.; Dong, W.-H.; Ding, X.-P.; Jiang, B.; Mándi, A.; Kurtán, T.; Mei, W.-L.; Dai, H.-F., New tricyclic prezizaane sesquiterpenoids from agarwood. Fitoterapia, 2019, 138, 104301.

 承担科研项目情况(限5项):(含纵向、横向和人才项目等)

  1. 国家自然科学基金(地区基金),项目编号:82460689,名称:羊角天麻新型抗疟活性成分作用靶点鉴定及先导化合物研究,01-2028.12,32万元,在研,参与。
  2. 大理大学博士科研启动基金,项目编号:KYBS2024008,名称:植物内生微生物抗疟活性成分研究,2024.06-2029.06,20万元,在研,主持。
  3. 云南省地方本科高校基础研究联合专项资金项目-青年项目,项目编号:202401BA070001- 054,名称:羊角天麻内生微生物及其次级代谢产物研究,2024.09-2027.08,5万元,在研,主持。