姓    名：杨自忠                                       

专业方向：生药学

办公电话：0872-2214251

电子邮件：yangzzh69@163.com

通讯地址：云南省大理州大理市下关镇万花路22号大理大学下关校区

简历：杨自忠，教授，博士生导师，中国动物学会蛛形学专业委员会委员。主要从事从事药用蜘蛛系统学研究和蜘蛛基因组及其毒素多组学研究研究。主持和参与各类科研项目17项，其中国家自然科学基金5项、云南省科技厅基础研究重点2项和面上项目1项、主持云南省科技厅生物医药重大专项子项目1项。已发表相关的科研论文140余篇，其中42篇被SCI索引，中科院分区一区2篇，二区11篇，三区8篇，四区21篇，文章目录。主编《云南蜘蛛名录》和《云南常见蜘蛛》，参编《中国蜘蛛生态大图鉴》。发现和发表蛛形动物新种120种。获得发明专利3项。已培养13位药学硕士研究生。

研究领域：①云南蜘蛛区系分类及其演化；②大疣蛛科蜘蛛资源、系统学、基因组及毒素研究；③蜘蛛资源天然产物发掘及开发利用。

代表论著（限10篇）：

1. Zhi Li, Mengmeng Zhang, Wenhao Yin, Yulin Zheng, Heng Liu, Yu Zhao, Zizhong Yang*. Serine proteases and serine protease inhibitors identified from the venom gland transcriptome of Rhitymna verruca. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 58 (2026) 101719. 1-13.
2. Yulin Zheng, Wenhao Yin, Luke R. Tembrock, Menghui Yang, Mengmeng Zhang,Yu Zhao*, Zizhong Yang*.Integrative transcriptomic and proteomic analysis reveals the toxindiversity of the spider Macrothele bannaensis. International Journal of Biological Macromolecules, https://doi.org/10.1016/j.ijbiomac.2025.146740.
3. Mengmeng Zhang, Wenzheng Cai, Menghui Yang, Mengying Zhang, Luke R. Tembrock, Zhibin Yang*, Heng Liu*, Zizhong Yang*.Transcriptomic and proteomic analyses reveal the diverse components in the venom of a recently described spider species Macrothele washanensis. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 55 (2025) 101491
4. Wenhao Yin, Yongming You, Luke R. Tembrock, Mengmeng Zhang, Zhi Li, Yulin Zheng, Yu Zhao*, Zizhong Yang*. Transcriptomic and proteomic analyses reveals the diverse venom composition of the spider Neoscona shillongensis. Insect Biochemistry and Molecular Biology, 180 (2025) 104289. https://doi.org/10.1016/j.ibmb.2025.104289
5. Yulin Zheng, Yu Zhao, Zizhong Yang*. Description of three new species of genus Vacrothele(Araneae, Mygalomorphae, Macrothelidae) from China with notes on two taxonomic amendments. European Journal of Taxonomy, 2025, 976: 92-107.
6. Menghui Yang, Wenzheng Cai, Luke R. Tembrock, Mengmeng Zhang, Mengying Zhang, Yu Zhao*, Zizhong Yang*. Transcriptomic analyses reveals a diverse venom composition in Agelena limbata(Araneae: Agelenaidae). Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2024, 52 (2024) 101303 2024/07/31
7. Xiao-liang, Gu,Ying Wang, Cheng-gui Zhang, Xiu-mei Wu, Huai Xiao, Yin-he Yang, Da-song Yang, Zhi-bin Yang, Yu Zhao & Zi-zhong Yang*. Proteomics, Peptidomics and Transcriptomic Analysis of the Venom from the Spider Macrothele yani (Mygalomorphae: Macrothelidae). Current Proteomics, 2022, 19, 308-322.
8. Yongming You, Yani Tang, Wenhao Yin, Xinxin Liu, Pengfei Gao, Chenggui Zhang, Luke R. Tembrock*, Yu Zhao**, Zizhong Yang**. From genome to proteome: Comprehensive identiffcation of venom toxins from the Chinese funnel-web spider (Macrothelidae: Macrothele yani). International Journal of Biological Macromolecules, https://org/10. 1016/j. ijbiomac. 2024.131780
9. Mengmeng Zhang, Yaying Wu, Yu Zhao* & Zizhong Yang*. Two new species of the genus MacrotheleAusserer, 1871 from Yunnan Province, China (Araneae: Macrothelidae). European Journal of Taxonomy, 2024, 932: 69-81.
10. Yongming You, Wenhao Yin, Luke R. Tembrock, Zhiqiang Wu, Xiaoliang Gu, Zhibin Yang, Chenggui Zhang, Yu Zhao, Zizhong Yang*. Transcriptome sequencing of wolf spider Lycosa (Araneae: Lycosidae) venom glands provides insights into the evolution and diversity of disulfide-rich toxins.Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2023, 48 (2023) 101145 

承担科研项目情况（限5项）：

主持和参与各类科研项目如下：

1. 国家自然科学基金项目—火烧遗迹地蜘蛛群落演替研究（31060070），01-2013.12，22万，主持，已结题；
2. 云南省科技厅应用基础研究重点项目—西南地区异纺蛛科蜘蛛物种多样性及蛛毒活性肽筛选（2016FA012），10. -2019.09，50万，主持，已结题；
3. 云南省科技厅重大科技专项（生物医药）—生物资源数字化开发应用（202002AA100007）子项目，2020.07. -2023.06，15万，主持，已结题；
4. 国家自然科学基金项目—中国西南地区大疣蛛科蜘蛛系统学研究（32160113），2021.01. -2025.12，36万，主持，已结题；
5. 云南省科技厅应用基础研究重点项目—大疣蛛科蜘蛛毒素多肽分子多样性及活性多肽毒素筛选（202301AS070083），2024.03. -2027.02，50万，主持，在研。